Studies on Sphingosines. 9. C19-Sphingosines, hitherto Unknown Sphingosines.
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چکیده
منابع مشابه
Sphingosines affect the adherence of Streptococcus gordonii and Streptococcus sanguinis on hydroxyapatite
Sphingosines affect the adherence of Streptococcus gordonii and Streptococcus sanguinis on hydroxyapatite. Abstract Sphingosines exhibit bactericidal activity on planktonic cells. However, their anti-adherence activity when adsorbed on hydroxyapatite (HA) surfaces is unknown. Therefore this study evaluated the anti-adherence activity of a variety of sphingosines and their derivatives against St...
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"Sphingosin" was first described by J. L. W. Thudichum in 1884 and structurally characterized as 2S,3R,4E-2-aminooctadec-4-ene-1,3-diol in 1947 by Herb Carter, who also proposed the designation of "lipides derived from sphingosine as sphingolipides." This category of amino alcohols is now known to encompass hundreds of compounds that are referred to as sphingoid bases and sphingoid base-like co...
متن کاملSphingosines Derived from Marine Sponge as Potential Multi-Target Drug Related to Disorders in Cancer Development
Haliclona tubifera, marine sponge species abundant in Brazilian coastline, presents only a few papers published in the literature. Recently, we have reported the isolation of two modified C18 sphingoid bases: (2R,3R,6R,7Z)-2-aminooctadec-7-ene-1,3, 6-triol and and (2R,3R,6R)-2-aminooctadec-1,3,6-triol. In order to continue our research, in this work aimed at the biological investigation of frac...
متن کاملThe chemical nature of the fatty acids of brain and spleen sphingomyelin; the occurrence of saturated and unsaturated sphingosines in the sphingomyelin molecule.
Sphingomyelin prepared with the older methods from brain and spleen yielded on acid hydrolysis palmitic, stearic, and lignoceric acids (1, 2). Mere found that in addition to these saturated acids nervonic acid is present in the sphingomyelin of brain (3). The presence of palmitic acid in the sphingomyelin molecule of brain seemed questionable, since it was shown that sphingomyelin prepared by t...
متن کاملHuman acid beta-glucosidase: use of sphingosyl and N-alkyl-glucosylamine inhibitors to investigate the properties of the active site.
Human acid beta-glucosidase (D-glucosyl-N-acylsphingosine glucohydrolase, EC 3.2.1.45) cleaves the beta-glucosidic bonds of glucosylceramide and synthetic beta-glucosides. The specificity of binding to the active site of this enzyme was evaluated using series of inhibitors including synthetic sphingosines, N-alkyl(Cn)-deoxynojirimycins (1,5-dideoxy-5-iminoglucose) and N-Cn-glucosylamines. The s...
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ژورنال
عنوان ژورنال: Acta Chemica Scandinavica
سال: 1965
ISSN: 0904-213X
DOI: 10.3891/acta.chem.scand.19-2423